Originally the Slackware Internationalization project, Slint is now a Linux distribution derived from Slackware and Salix. It is polyglot, versatile, beginner friendly, and accessible for the visually impaired, cf.:
http://slackware.uk/slint/x86_64/slint-14.2.1/doc/Accessibility/
A full Slint installation is functional out of the box and can be tailored to fit most computing requirements.